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By 02 Posts SZD_Post 08-32

22 de April de 2019

BZ043, a novel long-acting amylin analog, reduces gastric emptying, food intake, glycemia and insulin requirement in streptozotocin-induced diabetic rats

Amylin analogs are important adjunctive drugs in the treatment of diabetes mellitus. However, a dual therapy with insulin involves inconvenient multiple injections. Here we describe a novel n-terminal PEGylated human amylin analog – BZ043 – and its potential to improve the control of glycemia using lower doses of insulin. The effect of BZ043 over the insulin-mediated control of fed-glycemia was investigated in rats with streptozotocin-induced diabetes treated with the basal analog glargine (GLAR). Fasted rats (3 h) received a single treatment of BZ043 (16, 64 or 128 nmol/kg), GLAR (1.5 IU or 6.0 IU) or BZ043 plus GLAR low dose (1.5 IU) in separate injections, and had free access to 5% glucose rich chow and water. BZ043 dose-proportionally prevented the meal-related increase of glycemia, and the co-treatment (64 or 128 nmol/kg) with GLAR restored normoglycemia without abrupt variations of glycemia. BZ043 showed a prolonged anti-hyperglycemic effect and, together with GLAR, promoted a long-lasting normoglycemia, in vivo. We conceive that combining BZ043 and GLAR in a fixed-ratio co-formulation might conveniently improve the control of diabetes mellitus.
 
Access the full paper co-authored by our patent specialist Caio França by clicking here.
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Last by 02 Posts SZD_Post 08-32

26 de November de 2020

ANVISA published manuals related to prior consent of patent applications

The Brazilian FDA (ANVISA) published on November 19, 2020, four manuals regarding the analysis of prior consent of patent applications related to ANVISA published manuals related to prior consent of patent applications

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10 de July de 2019

BPTO publishes resolutions that will initiate the “Patent Backlog-fighting Project”

As part of the “Patent Backlog-fighting Project”, the Brazilian Patent and Trademark Office (BPTO) published Resolutions INPI Nos. 240/19 and 241/19 on BPTO publishes resolutions that will initiate the “Patent Backlog-fighting Project”

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22 de April de 2019

BZ043, a novel long-acting amylin analog, reduces gastric emptying, food intake, glycemia and insulin requirement in streptozotocin-induced diabetic rats

Amylin analogs are important adjunctive drugs in the treatment of diabetes mellitus. However, a dual therapy with insulin involves inconvenient multiple injections. BZ043, a novel long-acting amylin analog, reduces gastric emptying, food intake, glycemia and insulin requirement in streptozotocin-induced diabetic rats

Ler notícia
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